Most epilepsy drugs should not be stopped in pregnancy because the loss of seizure control outweighs the risk of fetal malformations for most drugs, an Australian study shows. Analysis of data from 148 women with epilepsy who went untreated during pregnancy found they faced a high risk of seizures but showed no reduction in fetal malformation rates. And figures derived from more than 1700 women in the Australian Register of Anti-Epilepsy Drugs in Pregnancy showed that fetal malformation rates were similar for pregnancies of treated and untreated women when the teratogens valproate and topiramate were excluded. Untreated women had 20% higher rates of seizure of any type during pregnancy compared with treated women, according to the study in the journal Seizure. Lead author...
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